Taranabant is a cannabinoid 1 receptor changed agonist that was in development for analysis of obesity. Because of axial afraid arrangement effects, the abstraction was performed to appraise the corruption abeyant and cerebral furnishings of taranabant in recreational polydrug users compared with phentermine, dronabinol, and placebo.
Stimulant- and cannabis-experienced polydrug users (N = 30) were randomized in a double-blind crossover abstraction to accept taranabant 2, 4, 10, and 20 mg; phentermine 45 and 90 mg; dronabinol 20 mg; and placebo. Abstract and neurocognitive measures were administered for 24 hours, and peak/peak change from baseline furnishings were analyzed application a beeline mixed-effects model.
Phentermine 45 and 90 mg showed abuse-related abstract furnishings against placebo, including biologic liking, all-embracing biologic liking, and added positive/stimulant effects, admitting dronabinol 20 mg showed abuse-related positive, cannabis-like, and allaying effects. Taranabant was not decidedly altered from placebo on a lot of of the abstract measures added than negative/dysphoric furnishings at the accomplished dose, and its furnishings were decidedly beneath arresting about to phentermine and dronabinol on a lot of measures. Phentermine bigger cognitive/motor achievement and dronabinol broken motor/cognitive achievement on some measures, admitting taranabant 4 and 20 mg had accessory crime furnishings on chiral tracking.
The phentermine and dronabinol after-effects authenticate the authority and acuteness of the study. Taranabant did not consistently appearance stimulant/cannabis-like furnishings or corruption abeyant in recreational polydrug users, advertence that cannabinoid 1 receptor changed agonists/antagonists are absurd to be recreationally abused.
