Psoralea corylifolia L. (Fabaceae) is a broadly acclimated medical bulb in China. This abstraction was advised to awning and analyze bioactive compounds with anticancer action from the seeds of Psoralea corylifolia L. One airy atom (fraction I) and three added fractions (fraction II, III, IV) from booze abstraction of P. corylifolia L. were obtained. Bioactivities of these fractions were evaluated by the cytotoxicity on KB, KBv200, K562, K562/ADM blight beef with MTT assay. Above apparatus in the alive atom were articular by HPLC/MSn. Atom IV decidedly inhibits the advance of blight beef in a dose-dependent manner. The IC50 ethics were 21.6, 24.4, 10.0 and 26.9, respectively. Psoralen and isopsoralen, abandoned from atom IV, were accountable to bioactive appraisal and presented a dose-dependent anticancer action in four blight corpuscle curve (KB, KBv200, K562 and K562/ADM). The IC50 ethics of psoralen were 88.1, 86.6, 24.4 and 62.6, which of isopsoralen were 61.9, 49.4, 49.6 and 72.0, respectively. Apoptosis of bump corpuscle decidedly added afterwards advised with psoralen and isopsoralen. Consecration of apoptotic action was accepted by breeze cytometry afterwards staining with Annexin V/PI. These after-effects appropriate psoralen and isopsoralen accord to anticancer aftereffect of P. corylifolia L.
from:Rare Metals
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