Acadesine (INN), as able-bodied as 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, AICAR riboside and AICAR, an AMP protein kinase activator is activated, which is acclimated for the analysis of astute lymphoblastic leukemia, and may accept appliance in the analysis of added diseases such as diabetes.
Acadesine (AICA riboside) is a purine nucleoside anti-ischemic backdrop that are currently getting advised (Phase 3) for the blockage of adverse cardiovascular outcomes in patients coronary avenue bypass affix (CABG) surgery. It is accordingly developed PeriCor and Schering-Plough.
Acadesine-induced apoptosis aswell appears the absolution of cytochrome c from mitochondria and activation of caspase appeal and p53 independent.Acadesine is adenosine acclimation agents advised PeriCor Therapeutics and accountant to Schering-Plough in 2007 for the Appearance III studies.
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