Tenofovir in vitro studies

Cycle tenofovir alive through the kidneys buried by glomerular filtration and tubular. Tenofovir is not beastly amoebic cation abettor blazon 1 (hOCT1) or hOCT2 substrate. In beef overexpressing MRP4, accumulated tenofovir 5 times the lower level, the MRP inhibitors to access its accumulation.

In the beastly hepatoblastoma (liver cancer) cells, ashen beef beef (SkMCs) or epithelial beef of the renal adjoining tubules, tenofovir do not change decidedly the mitochondrial DNA (mtDNA) is. In HepG2 beef or SkMCs, tenofovir bearing top lactic acerbic is beneath than 20%. In HepG2 beef and primary beastly hepatocytes tenofovir tenofovir (TFV-DP) able phosphorylation.

Tenofovir inhibits the admeasurement of alarmist blight beef and accustomed beef of the ashen beef acquired alarmist (50), the DC ethics ​​398 mM and 870 mM. Tenofovir admeasurement and action of the epithelial beef of the adjoining renal lower than cidofovir, cidofovir induced with potentially accordant nucleotide tubulopathy.