The effect of reserpine principle

Reserpine for adrenergic nerve inhibition of drugs, can prevent the adrenergic nerve peripheral storage within the medium, and will have booster effect of medium in the vesicle depletion. Double hydrazine sulfate flexor lamictal for, vasodilators can loose small artery smooth muscle, reduce the peripheral resistance. Hydrochlorothiazide for diuresis antihypertensive agents. Three drugs combined use of a significant synergies, promote the blood pressure to drop, increase the curative effect, reducing the dose of each drug and adverse drug reactions, at the same time, hydrochlorothiazide can increase the blood and double hydrazine sulfate oxazine antihypertensive effect; Also can reduce the side effects of their water sodium retention.



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Natural Herbal Extracts

Kaolin adsorption method extracting Bromelain （2）

Take clean fresh pineapple juice yield, such as skin, thorn, core of more than 45% of scraps, squeezing, fruit juice filter chip. The filtrate adds 0.025 0.05% benzoic acid, and 0.05% kaolin for adsorption. Dispatch kaolin adsorption material with saturated sodium carbonate solution pH6.7-7.0, and 5% sodium chloride, stirring after filter. Take the filtrate hydrochloric acid pH4.8-5.1, and ammonium sulfate, let stand for precipitation, precipitation decompression drying, is the bromelain. Process is as follows: pineapple scraps (press) to SAP (kaolin) adsorption, adsorption content (elution, filter) and eluent (salting out) - salting out content (centrifugal) - wet crude enzyme cake (dissolving, filtering) to clarify the content (precipitation), wet enzyme (dry) and high-quality goods
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pharmacological and characteristics of Cephalexin

The goods is crystal powder of white or part; Slight odor. Only slightly soluble in water, insoluble in ethanol, chloroform or ethyl ether. Than the curl to take the goods, precision said, adding water to dissolve and diluted into each 1 ml contains 5 mg solution, determined in accordance with the law, than the curl of + 144 degrees to + 158 degrees. Absorption coefficient for the goods, precision said, adding water to dissolve and diluted into each 1 ml contains about 20 mu g solution, as spectrophotometric method, the determination of absorbance at the wavelength of 262 nm, absorption coefficient of 220 ~ 245.
The goods by inhibiting the synthesis of cell wall, dissolve the cell contents swelled to burst, so as to achieve the sterilization effect. The goods of broad spectrum antibiotics. To gram-positive bacteria and gram-negative bacteria are antimicrobial effect, absorbs quickly and completely after injection, high bioavailability. Specially add synergistic anti-inflammatory factor, make the goods be effect, its sterilization ability 20 times larger than the penicillin class, 10 times larger than sulfa, five times larger than quinolone class.
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The use of genetic engineering to the preparation of L - threonine

Is the earliest in the late 1970 s, the Soviet union's researchers will threonine engineering bacterium used in industrial production of threonine, the synthesis of threonine gene from small plasmid into another cell, by gene amplification, threonine synthase expression increase so as to improve the output of threonine. Produced by biosynthesis of amino acid, prepared by the bacteria and enzymes is the key, natural amino acid can be found in some species and enzyme, some are difficult to find, make the production of amino acids is restricted. In recent years, with the development of chemical industry, with chemical synthesis or chemical synthesis combined with biological technology to the preparation of amino acids, amino acids in the industry plays a more and more important role.

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Dehydrocostus lactone role in medicine

Dehydrocostus lactone herbs commonly used for domestic and foreign, in our country contained in the "Shen Nong's Herbal Classic", has gas pain, the effect of temperature and stomach for abdominal pain, vomiting, diarrhea, dysentery, tenesmus, food plot Needless embolism. In recent years, with the increasing depth aspects of Dehydrocostus lactone plant chemical constituents, pharmacological activities, such as research and clinical application, proof of its anti-cardiovascular disease, anti-inflammatory, anti-cancer, anti-ulcer, anti-pathogenic microorganisms and other aspects exhibit good pharmacological activity. However, due to a long history of drug use Dehydrocostus lactone, its substitutes, local learning supplies, confusion of types more presence homonym, a multi-drug-based sources, which is not conducive to control the safety and efficacy of medicinal quality, it is difficult to ensure that clinical efficacy. Therefore, this species of Dehydrocostus lactone conducted research, carried out a comprehensive overview of the latest research progress of the active ingredient and its pharmacological activity in order to provide reference for further rational development and utilization of wood resources of medicinal plants.


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Description of prior art 4-bromophenylacetic

A process for preparing methyl 2-(4-bromophenyl)-2-methylpropanoate is disposed in J. Org. Chem. 1994, 59, 2620-2622. Herein, methyl 2-(4-bromophenyl)-2-methyl propanoate is prepared by esterification of 4-bromophenylacetic acid followed by methylation of the benzylic carbon employing 2.4 equivalents of methyl iodide in the presence of sodium hydride in a tetrahydrofuran medium. However, the process of selective bromination either from phenyl acetic acid or from 2-methyl-2-phenylpropanoic acid is not described. The efforts of the present inventors did not result in industrial application of this process due to the following drawbacks:
1) Preparation of 4-bromophenylacetic acid requires multistep synthesis.
2) Trimethyl chlorosilane and methyl iodide reagents are expensive to use on commercial scale.
3) Sodium hydride is a highly flammable material and an industrially hazardous reagent.
4) Tetrahydrofuran used as a solvent is also expensive to use on a commercial scale.
5) The reaction is highly exothermic.

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2-Chloro-3-methoxypyridine of PHYSICAL AND CHEMICAL

PROPERTIES
Physical State : Liquid
Appearance : Colorless to light yellow
Odor : Not available.
pH : Not available.
Vapor Pressure : Not available.
Viscosity : Not available.
Boiling Point : 192-193 degC @ 760mmhg
Freezing/Melting Point : Not available
Autoignition Temperature : Not available.
Flash point : 79 deg C (174.20 deg F)
Explosion limits : Lower : Not available
Explosion limits : Upper : Not available
Solubility in water : Not available.
Specific Gravity/Density : 1.170
Molecular Formula : C6H6ClN
Molecular Weight : 127.57

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