Monoammoniumglycyrrhizinate (MAG) was the aglycone of glycyrrhizin acquired from licorice. In this study, the anti-inflammatory furnishings of MAG on lipopolysaccharide (LPS)-induced astute lung abrasion (ALI) in mice and the accessible mechanisms complex in this aegis were investigated. Pretreatment with MAG above-mentioned to the administering of intratracheal LPS decidedly induced a abatement in lung wet weight/dry weight ratio, in absolute corpuscle bulk and neutrophil percent in the BALF, and in myeloperoxidase (MPO) action of lung in dose-dependent manners. At the aforementioned time, pretreatment with MAG aswell decidedly bigger the cool oxide dismutase (SOD) action and induced the malondialdehyde (MDA) agreeable in the bronchoalveolar lavage aqueous (BALF). Importantly, pretreatment with MAG prevented an access in circadian adenosine monophosphate-phosphodiesterase (cAMP-PDE) action of lung in a dose-dependent manner. In addition, it can up-regulate the interleukin-10 (IL-10) akin and down-regulate the bump aberration factor-α (TNF-α) akin in the lung tissue of ALI mice. These after-effects showed that anti-inflammatory furnishings of MAG adjoin the LPS-induced ALI may be due to its adeptness of primary inhibition of cAMP-PDE activity, oxidative accent and its adjustment of cytokine effects. Thus the after-effects abutment that use of MAG is benign in the assay of ALI and ARDS.
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