Study found that platelets play an important role in the formation process of thrombosis, coagulation reaction in vivo thrombus formation starting in platelet activation. Not activated platelet surface, P- selectin low expression or no expression. When the platelets and endothelial cells are stimulated, rod bodies and platelet α particle membrane fusion with the cell membrane rapidly, P- selectin quickly transferred from the platelets and platelet α in vivo rod small particles to the cell surface, and polymorphonuclear leukocytes and mononuclear cell adhesion, fusion with the plasma membrane surface of platelets in platelet activation, so that P- selectin expression on platelets in the plasma membrane or appear in a few seconds to a few minutes P- selectin expression to new heights. In P- selectin-mediated platelet, leukocyte and endothelial cell adhesion, increased blood viscosity, blood is hypercoagulable state promote thrombosis. By P- selectin and platelet monocyte adhesion, formation of fibrin into a lake, promote thrombosis and stability. The high concentrations of plasma P- selectin, can improve the adhesion of neutrophils and platelets and fibrin between, and after the experiment confirmed a dose-dependent relationship, P- selectin adjustable neutrophil adhesion, parts of low shear can have a higher concentration P- selectin promote aggregation of leukocytes to sites of vascular injury and promote the disease process.
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