Cluster of adverse
24(CD24) is a corpuscle adherence atom that has been alive in bump aggression
and alteration of assorted solid tumors. The aim of this abstraction was to
analyze the announcement patterns of CD24 as a predictive brand for abiding
adaptation in cervical carcinomas.
METHODS:
A absolute of 144
patients diagnosed with International Federation of Gynecology and Obstetrics
date I to IV cervical blight were studied, and 95 patients underwent surgical
intervention. The announcement of CD24 protein was advised by
immunohistochemistry application tissue microarrays.
RESULTS:
Overexpression of CD24
was empiric in 50 (34.7%) of 144 invasive carcinomas. Patients with CD24
overexpression had poorer adaptation compared with that of patients with CD24
underexpression (5-year adaptation rate, 52.0% vs 72.3%; log rank P = 0.014).
Importantly, in multivariate analysis, CD24 overexpression accepted to be a
cogent absolute augur of concise adaptation (relative risk, 1.814; P = 0.043).
CONCLUSIONS:
The present abstraction
suggests that CD24 overexpression is a augur of decreased abiding adaptation in
patients with cervical carcinoma. Therefore, immunohistochemical appraisal of CD24
announcement is a abeyant anxiety biomarker for cervical carcinomas.
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