PTP-1B catalytic cysteine thiol group functional domains essential for the activity of the enzyme, which is required to maintain the reduced state, any compound that would make the oxidation leads to the loss of enzyme activity. Studies suggest that PTP-1B inhibitors can weaken the role of dephosphorylation by PTP-1B receptor for insulin and improve insulin receptor and its substrate level phosphorylation -1, played insulin and insulin-sensitizing.
Vanadate and vanadium peroxide compounds: vanadate and phosphate has a similar structure, the role of alternative PTPase substrate inhibition is associated with insulin derivative-related PTPase activity involved in insulin signal transduction activation of tyrosine kinases. Vanadate (Na3VO4, etc.) reversible competitive inhibition (reversible oxidation) PTP-1B, while the ethylenediamine tetraacetic acid was added to the enzyme, vanadate inhibition of PTP-1B will be reversed.
Peroxovanadate PTPase through irreversible oxidation of the active site Cys thiol group from irreversible inhibition mechanism peroxovanadate hypoglycemic by inhibiting insulin signal transduction related PTPase and activate the insulin receptor kinase.
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Anti-PTP-1B/pTyr (Protein-tyrosine phosphatase, non-receptor :p-tyr) prices
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Elisa assay kits
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